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产品目录

PI3 Kinase p110 Alpha/PIK3CA抗体图片
产品货号:
Z23840
中文名称:
PI3 Kinase p110 Alpha/PIK3CA抗体
英文名称:
Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody
指标别名p110 alpha;PI3 kinase subunit alpha;PI3K;PI3K alpha;PI3K p110(alpha);PIK3CA;PtdIns 3 kinase subunit alpha
克隆性Polyclonal
检验物种human,mouse,rabbit,rat
应用范围IHC
基因名称PIK3CA
抗体来源Rabbit
抗体类型IgG
免疫原E.coli-derived human PIK3CA recombinant protein (Position:H936-N1068).Human PIK3CA shares 98% amino acid (aa) sequence identity with mouse PIK3CA.
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Phosphatidylinositol-4,5-bisphosphate 3-kinase,also called PIK3CA,is composed of an 85kDa regulatory subunit and a 110kDa catalytic subunit.PIK3CA gene is mapped to 3q26.32.The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate phosphatidylinositols (PtdIns),PtdIns4P andPtdIns(4,5)P2.Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers.It has been found to be oncogenic and has been implicated in cervical cancers.PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy.In addition to that,the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer,indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.
Uniprot IDP42336
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha
蛋白名全称Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
推荐稀释比
Immunohistochemistry in paraffin section IHC-(P) 1:50~400
(Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

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